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. 2014 Aug 11;5:379. doi: 10.3389/fimmu.2014.00379

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Copyright © 2014 Gerriets and MacIver.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adipose tissue is remodeled following high-fat diet-induced obesity. Multiple immune cells reside in adipose tissue. High-fat diet-induced obesity results in decreased regulatory T cells (Treg) and alternatively activated M2 macrophages. At the same time, there is an increase in adipose-resident inflammatory macrophages (classically activated M1 macrophages), CD4+ Th1 cells, CD8+ T cells, and B cells. The role of CD4+ Th2 and Th17 cells in adipose tissue in obesity is less certain.