Table 1.
Gene | Variants (SNPs) | Population-Ethnic group | Association | Ref. |
IL-1α | -889 | NS | [26] | |
IL-1β | 3954 | |||
IL-1β | -511 | |||
IL-1Ra | VNTR | |||
IL-1α | 3'UTR | Caucasians and African Americans | S | [27] |
IL-1 | C-889T | East Indian | S | [28] |
IL-1β | C-511T | |||
IL-1β | C3953T | |||
IL-1α | S | [29] | ||
IL-Ra | VNTR | |||
IL-1β | C3954T | S | [30] | |
IL-1β | -511 | North Indian | S | [31] |
IL-1Ra | VNTR | |||
IL-1β | C-511T | S | [32] | |
IL-1Ra | VNTR | |||
IL-1β | C-511T | Korean | S | [33] |
IL-1Ra | VNTR | |||
IL-1Ra | VNTR | NS | [29] | |
IL-1Ra | VNTR | S | [34] | |
IL-1Ra | VNTR | North Indian | S | [17] |
IL-1Ra | VNTR | Caucasians | NS | [35] |
IL-1Ra | VNTR | S | [36] | |
IL-1RI | PstI, HinfI, AluI (promoter region) | Dalmatian population of South Croatia | S | [37] |
PstI (exon 1B region) | ||||
IL-18 | +183 A/G | Norwegian | S | [38] |
-137 G/C | NS | |||
-607 C/A | NS | |||
-607 C/A | Chinese | S | [39] | |
BCO2 | European | S | [40] | |
rs2250417 | European | NS | [41] | |
5 SNPs | European | S | [42] |
UTR: Untranslated region; VNTR: Variable number of tandem repeats; S: Significant; NS: Nonsignificant; IL-1: Interleukin-1; SNPs: Single nucleotide polymorphisms.