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. 2014 Aug 10;5(3):299–310. doi: 10.5306/wjco.v5.i3.299

Figure 1.

Figure 1

Breast tumour kinase domain structure. Full length Brk/PTK6 and short isoform ALT-PTK6 structure indicating the SH3 domain (green), SH2 domain (orange) and a tyrosine kinase domain or proline rich sequence (blue). Underneath is indicated the cDNA structure of both forms, with each box indicating each exon (total of 8 exons). ALT-PTK6 has deletion at exon 2 and lacks SH2 domain due to shift in open reading frame, which gives a proline rich sequence at exon 3 instead. PTK6: Protein tyrosine kinase 6; Brk: Breast tumour kinase.