Table 3. Dose Duration, Cumulative Dose and Dose Intensity (in median [range]) of Oxaliplatin and 5-Fluorouracil.
| Parameters | Asian Studies | Western Studies | ||||||
|---|---|---|---|---|---|---|---|---|
| J-PMS | MASCOT | EFC2962 | N9741 | EFC4584 | MOSAIC | |||
| PUT | PT | Total | ||||||
| FOLFOX4 | ||||||||
| Treatment, wk | 21 (2-89) | 16 (2-104) | 17 (2-104) | 26 (2-43) | 28 (2-93) | 24 (2-98) | 18 (2-71) | 26 (2-42) |
| Treatment cycles | 8 (1-31) | 6 (1-34) | 7 (1-34) | 12 (1-12) | 12 (1-35) | 10 (1-47) | 7 (1-28) | 12 (1-12) |
| Oxaliplatin | ||||||||
| Cumulative dose (mg/m2) | 657 (80-2635) | 500 (21-2912) | 510 (21-2912) | 967 (85-1036) | 839 (83-2356) | 765 (84-2959) | 589 (83-2253) | 888 (7-1064) |
| Dose intensity (mg/m2/week) | 33 (12-45) | 33 (11-47) | 33 (11- 47) | 35 (17-43) | 33 (9-52) | 36 (9-50) | 36 (18-50) | 34 (3-44) |
| Bolus 5-Fluorouracil | ||||||||
| Cumulative dose (mg/m2) | 5600 (774-24,812) | 4505 (0-27,411) | 4668 (0-27,411) | 8598 (800-9720) | 8624 (400-27,821) | 6299 (0-37,612) | 5471 (0-22,357) | 8483 (0-10,107) |
| Dose intensity (mg/m2/week) | 297 (71-413) | 299 (0-444) | 298 (0-444) | 319 (196-402) | 320 (196-405) | 309 (0-546) | 338 (0-410) | 332 (0-421) |
| Infusion 5-Fluorouracil | ||||||||
| Cumulative dose (mg/m2) | 9307 (1158-46,375) | 7133 (0-42,772) | 7200 (0-46,375) | 13,400 (1200-14,815) | 13,188 (600-41,732) | 9581 (0-55,227) | 8347 (0-33,537) | 13,200 (0-15,918) |
| Dose intensity (mg/m2/week) | 471 (180-843) | 468 (0-1125) | 470 (0-1125) | 496 (301-603) | 486 (300-604) | 467 (0-638) | 510 (0-830) | 509 (0-663) |
Abbreviations: FOLFOX4 = 5-fluorouracil/leucovorin/oxaliplatin; J-PMS = Post Marketing Surveillance study; PT = previously treated with chemotherapy; PUT = previously untreated with chemotherapy.