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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Neurobiol Aging. 2014 May 2;35(10):2272–2281. doi: 10.1016/j.neurobiolaging.2014.04.031

Fig. 1.

Fig. 1

Effects of PERK haploinsufficiency on eIF2α phosphorylation in 5XFAD mice. (A, C) Representative immunoblots of protein extracts from hippocampal homogenates of mice. (B, D) Immunoreactive bands were quantified and expressed as the percentage of 5XFAD (B) or wild-type control (D) mice. The number of animals used is indicated on top of each column. Note that blocking PERK overactivation significantly suppressed increases in eIF2α phosphorylation in 5XFAD mice without changes in total eIF2α levels. Meanwhile, levels of phosphorylated eIF2α were indistinguishable between PERK+/− and wild-type mice. All data are presented as mean ± SEM and were analyzed by one-way ANOVA followed by post-hoc Fisher’s PLSD test (* p < 0.05 vs. wild-type, # p < 0.05 vs. 5XFAD).