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. 2014 Aug;86(2):159–167. doi: 10.1124/mol.114.092338

Fig. 8.

Fig. 8.

Effects of toxins on outward Igp fluxing through Nav 1.5. Typical outward Igp current traces and associated I–V curves before and after toxin treatment are shown. (A) Effect of ProTx-II on DI outward Igp. (B) Effect of the mixture of ApB (100 nM) and HWTX-IV (1 μM) on DI outward Igp. (C) Effect of ProTx-II on DII outward Igp. (D) Effect of HWTX-IV on DII outward Igp. All currents before (left) and after (right) toxin treatment were elicited by 100-ms depolarizing steps to various potentials that ranged from –100 to +70 mV. No subtraction of linear leak and capacitance currents was performed for current traces. The dotted line across current traces represents the zero current level. Cells were pretreated with 1 μM TTX to completely block the central-pore current and held at –100 mV. Note that in the I–V curves, linear leak currents have been subtracted. *P < 0.05; #< 0.01.