Table 2.
Sequence similarities and identification of DEGs
| Differentially expressed band | DEG | Identity | Sequence homology (%) | Accession number | UniGene number | Description |
|---|---|---|---|---|---|---|
| Overexpressed | ||||||
| A4.1 | DEG1 | Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 5 (PSMC5), mRNA | 502/506 (99%) | NM_002805.4 | Hs.79387 | Involves in the ATP-dependent degradation of ubiquitinated proteins |
| DEG2 | H. sapiens ubiquinol-cytochrome c reductase hinge protein (UQCRH), mRNA | 514/521 (98%) | NM_006004.2 | Hs.481571 | A component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex, which is part of the mitochondrial respiratory chain | |
| A4.2 | DEG3 | H. sapiens ribosomal protein S23 (RPS23), mRNA | 551/551 (100%) | NM_001025.4 | Hs.527193 | A component of the 40S subunit of human ribosomes |
| A6.1 | DEG4 | H. sapiens ribosomal protein L10 (RPL10), transcript variant 1, mRNA | 554/557 (99%) | NM_006013.3 | Hs.534404 | A component of the 60S subunit of human ribosomes |
| A9.2 | DEG6 | H. sapiens actin related protein 2/3 complex, subunit 2, 34 kDa (ARPC2), transcript variant 2, mRNA | 473/473 (100%) | NM_005731.2 | Hs.529303 | Involves in the regulation of actin polymerisation as an actin-binding component of the Arp2/3 complex, and mediates the formation of branched actin networks together with an activating nucleation-promoting factor |
| DEG7 | H. sapiens TIMP metallopeptidase inhibitor 1 (TIMP1), mRNA | 503/511 (98%) | NM_003254.2 | Hs.522632 | Irreversibly inactivates the metalloproteinase by binding to their catalytic zinc cofactor | |
| A10.1 | DEG8 | H. sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (ATP5B), nuclear gene encoding mitochondrial protein, mRNA | 917/919 (99%) | NM_001686.3 | Hs.406510 | A subunit of mitochondrial ATP synthase that catalyses the synthesis of ATP by utilising an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation |
| A13.2 | DEG11 | H. sapiens chromosome 11 open reading frame 10 (C11orf10), mRNA | 273/273 (100%) | NM_014206.3 | Hs.437779 | Unknown |
| A13.3 | DEG12 | H. sapiens mitochondrial ribosomal protein L24 (MRPL24), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA | 408/411 (99%) | NM_024540.3 | Hs.418233 | Involves in protein synthesis within the mitochondrion |
| A13.4 | DEG13 | H. sapiens similar to OK/SW-CL.16 (LOC100288418) | 635/644 (98%) | XM_002342023.1 | – | Unknown |
| A18.1 | DEG14 | H. sapiens family with sequence similarity 96, member B (FAM96B), transcript variant 2, transcribed RNA | 486/487 (99%) | NR_024525.1 | Hs.9825 | Involves in chromosome segregation as part of the mitotic spindle-associated MMXD complex |
| A20.1 | DEG15 | H. sapiens ribosomal protein L35 (RPL35), mRNA | 440/446 (99%) | NM_007209.3 | Hs.182825 | A component of the 60S subunit of human ribosomes |
| A20.2 | DEG16 | H. sapiens chromosome 6 open reading frame173 (C6orf173), mRNA | 551/554 (99%) | NM_001012507.2 | Hs.486401 | May be required for proper chromosome segregation during mitosis and involved with CENPT in the establishment of centromere chromatin structure |
| Underexpressed | ||||||
| A9.1 | DEG5 | H. sapiens ribosomal protein L37 (RPL37), mRNA | 284/284 (100%) | NM_000997.4 | Hs.731513 | A component of the 60S subunit of human ribosomes, and can bind to the 23S rRNA |
| A13.1 | DEG9 | H. sapiens solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 (SLC25A1), nuclear gene encoding mitochondrial protein, mRNA | 165/165 (100%) | NM_005984.2 | Hs.111024 | A mitochondrial tricarboxylate transporter which is responsible for the movement of citrate across the mitochondrial inner membrane |
| DEG10 | H. sapiens similar to cytochrome c oxidase subunit II (LOC100288578), miscRNA | 141/146 (97%) | XR_078216.1 | – | Unknown | |
DEG, differentially expressed gene.