Figure 1. Genotypic Effect of PhosSNP rs6265 on Hip BMD in Human Populations.
Presented are mean and S.E. Homozygous AA carriers lack wild-type protein BDNF-V66. The osteoblastic signaling pathways, regulated by BDNF-V66-mediated BDNF-T62 phosphorylation, probably are either blocked or attenuated, leading to inhibited bone formation and decreased BMD in humans.