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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: J Bone Miner Res. 2013 Dec;28(12):2498–2507. doi: 10.1002/jbmr.1997

Figure 1. Genotypic Effect of PhosSNP rs6265 on Hip BMD in Human Populations.

Figure 1

Presented are mean and S.E. Homozygous AA carriers lack wild-type protein BDNF-V66. The osteoblastic signaling pathways, regulated by BDNF-V66-mediated BDNF-T62 phosphorylation, probably are either blocked or attenuated, leading to inhibited bone formation and decreased BMD in humans.