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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: J Bone Miner Res. 2013 Dec;28(12):2498–2507. doi: 10.1002/jbmr.1997

Figure 5. Allele-Specific Effects of rs6265 on Osteoblastic Gene Expression (OPN and BMP2) in hFOB Cells.

Figure 5

Presented are mRNA abundance in hFOB cells. Raw data were normalized against the internal control GAPDH mRNA (mean and standard error). Negative control refers to empty vector transfection. The hFOB cells transfected with variant or mutant BDNF (M66T62 or V66A62) showed decreased OPN and BMP2 mRNA expression levels, compared with hFOB cells transfected with wild-type BDNF (V66T62). Experiments are in triplicates and repeated twice. *: P<0.05, as compared with V66T62.