Table 3.

Type-I error rates and power estimates under the major parameter settings.

Model	${\sigma }_{wp}^2$	${\sigma }_{bp}^2$	Type-I error (%)	Power (%)
				h2=0.2%	h2=0.4%	h2=0.6%	h2=0.8%	h2=1%
FE	0	0	5.0	75.2	99.1	99.9	100.0	100.0
	0	0.1	23.1	70.2	98.3	99.9	100.0	100.0
	0.6	0	27.3	69.0	97.1	99.9	100.0	100.0
	0.6	0.1	38.0	22.0	48.9	69.4	83.8	91.7
RE	0	0	3.8	41.5	75.6	89.4	95.7	98.6
	0	0.1	17.9	52.9	91.1	98.8	99.7	99.9
	0.6	0	8.1	13.4	43.9	71.9	86.5	94.4
	0.6	0.1	13.6	1.0	2.0	2.1	2.7	2.9

Note: “FE” and “RE” denote fixed-effects and random-effects models, respectively; ${\sigma }_{bp}^2$ and ${\sigma }_{wp}^2$ denote between- and within-population variances, respectively; h² represents heritability (phenotypic variation explained by the SNP). 10 individual GWA studies, each with 2,000 individuals, were included in the meta-analysis.