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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Cancer Prev Res (Phila). 2014 Mar 5;7(5):505–515. doi: 10.1158/1940-6207.CAPR-13-0296

Figure 1.

Figure 1

Estrogen metabolism and its relationship to chemical carcinogenesis. In breast epithelial cells, several SERMs were observed to modulate estrogen metabolism (as depicted by boxed arrows), in particular via modulation of detoxification enzymes: sulfotransferase, SULT; UDP-glucuronosyltransferase, UGT; NAPDH:quinone oxidoreductase, NQO1; glutathione-S-transferase-P1, GST. Catechol-O-methyl transferase (COMT) activity was not perturbed by SERMs. SERMs did not modulate expression of CYP450s in E2-treated cells.