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. 2014 Jul 25;171(16):3814–3826. doi: 10.1111/bph.12738

Figure 3.

Figure 3

Effects of local administration of melagatran on mechanical hypersensitivity. Mice received intraplantar injections of formalin (2.5%) (A), bradykinin (BK, 0.3 μg) (B), PAR2-AP (0.3 μg) (C), capsaicin (Cap., 5 μg) (D) or vehicle (Veh.). Melagatran (MGT) or vehicle was administered locally (430 ng, 10 μL, intraplantar, 15 min pretreatment). Formalin, bradykinin, PAR2-AP and capsaicin all caused a robust decrease in the nociceptive threshold for stimulation of the injected paws with von Frey filaments, consistent with mechanical hypersensitivity. Locally administered melagatran significantly inhibited mechanical hypersensitivity induced by formalin, bradykinin and PAR2-AP, but not to capsaicin. n = 6–16 mice per group. *P < 0.05, **P < 0.005, ***P < 0.001, proinflammatory and algesic agents significantly different from vehicle controls. #P < 0.05, ##P < 0.005, melagatran-treated mice receiving proinflammatory and algesic agents significantly different from vehicle controls.