Table 5.

Variants in the 15q25 gene cluster are associated with opioid dependence

			SAGE EA, n = 2772		SAGE AA, n = 1309		Combined, n = 4081
Phenotype	SNP	Allele	OR	P	OR	P	OR	P	Q_P
Withdrawal	rs112712252	G	0.31	7.3E−04	0.31	0.01	0.31	3.1E−05*	0.99
	rs190825809	C	0.33	0.001	0.32	0.02	0.33	9.6E−05*	0.98
	rs116932868	G	0.31	0.001	0.33	0.06	0.32	2.0E−04*	0.92
	rs16969968	A	1.15	0.22	1.49	0.32	1.17	0.14	0.54
DSM-IV	rs112712252	G	0.29	1.8E−04	0.27	0.006	0.28	3.5E−06*	0.91
	rs190825809	C	0.28	3.0E−04	0.28	0.01	0.29	1.1E−05*	0.91
	rs116932868	G	0.30	3.3E−04	0.28	0.03	0.28	2.4E−05*	0.99
	rs16969968	A	1.25	0.04	1.68	0.22	1.28	0.02	0.50

Association analysis conducted in the SAGE European American (EA) and African-American (AA) datasets shows that variants in the 15q25 gene cluster are significantly associated with a protective effect against opioid dependence. Uncorrected P values are shown for individual datasets. Cochran's Q statistic P values (Q_P) show no significant heterogeneity between datasets. Significant results are bold and underlined.

^*Denotes results that survived the single nucleotide polymorphism spectral decomposition correction for multiple testing threshold (P < 0.0006).