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. 2014 Jul 25;171(16):3868–3880. doi: 10.1111/bph.12748

Table 2.

EC50 values for DNA-methyltransferase inhibitors

EC50 (μM) 48 h pcDNA3.1 hCNT1 hCNT3
Azacytidine 29.5 ± 2 13.6 ± 0.7** 6.8 ± 0.7***
Decitabine >1000 >1000 >1000
Zebularine 62.0 ± 5.9 18.5 ± 6.6** 8.9 ± 2.0***

EC50 values were calculated by fitting data by non-linear regression in GraphPad Prism 4.0 software. Data are expressed as the mean ± SEM of at least three independent experiments performed on different days using different passages of cells. Unpaired Student's t-test was performed comparing the EC50 value for mock-transfected cells and hCNT1, hCNT3. (**P < 0.01; ***P < 0.001).