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Concentration-dependent changes in ERK1/2 phosphorylation of HEK293/GPR18 cells in the presence of NAGly (A), O-1918 (B), O-1602 (C), AbnCBD (D), and Δ9-THC (E). Significance (†P < 0.05, ††0.01, †††0.001) was determined by one-way anova with Bonferroni correction in comparison with control. * Indicates significant inhibition of the ligand response in the presence of PTX or NARA-S; one-way anova (*P < 0.05, **0.01, ***0.001) with Bonferroni correction.
