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. 2014 Jul 17;171(15):3651–3665. doi: 10.1111/bph.12716

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© 2014 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Comparison of GLP-1 receptor peptide ligands and relative bias factors. Sequences of the various peptide ligands for the GLP-1 receptor aligned to the potent, natural agonist. Amino acids differing from those in GLP-1 are highlighted in grey. The relative (to GLP-1) bias factor was quantified for each ligand as the change in log(τ/K_A) ratio where a negative value indicates preference for the inhibitory, Gαi chimera. Statistical significance was determined using one-way anova with Bonferroni's post-test with each data set compared with GLP-1 (**P < 0.01, ***P < 0.001). Data are mean of 5–8 independent experiments ± SEM.