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. 2014 Jul 17;171(15):3693–3701. doi: 10.1111/bph.12728

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© 2014 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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(A) Anti-hyperalgesic effect of CR4056 on postoperative pain-induced mechanical hyperalgesia in female rats (Randall-Selitto test). CR4056 was orally administered 24 h after surgery. Data represent the mean withdrawal threshold expressed in grams ± SEM (n = 6 per group). (B) Anti-hyperalgesic effect of morphine on postoperative pain-induced mechanical hyperalgesia in female rats (Randall-Selitto test). Morphine was subcutaneously administered 24 h after surgery. Data represent the mean withdrawal threshold expressed in grams ± SEM (n = 6 per group).