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. 2014 Jul 17;171(15):3702–3715. doi: 10.1111/bph.12725

Figure 5.

Figure 5

Effect of rutin on the central cholinergic dysfunction induced by BCCAO in rats. The levels of ACh, ChAT and AChE in the cerebral cortex and hippocampus were spectrophotometrically measured with assay kits. Vehicle-treated BCCAO rats had lower ACh level (A) and ChAT activity (B) and higher AChE activity (C) in the cerebral cortex and hippocampus compared with vehicle- and rutin-treated sham-operated rats. Whereas, rutin treatment in BCCAO rats significantly alleviated the decrease of ACh level (A) and ChAT activity (B) as well as the increase of AChE activity (C) compared with vehicle-treated BCCAO rats. Data are expressed as mean ± SEM (n = 10 rats per group). *P < 0.01 versus vehicle- and rutin-treated sham-operated rats; #P < 0.01 versus vehicle-treated BCCAO rats.