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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Biomaterials. 2014 May 29;35(25):6698–6706. doi: 10.1016/j.biomaterials.2014.05.008

Figure 4.

Figure 4

Delivery of the CCR2 agonist RS 102895 reduces neuroinflammation at 2 wks. Implant bearing mice were given IP injections of RS 102895 every day for 2 wks at doses of 3.0 and 0 mg/kg. Immunohistochemical stain for NeuN (A, B, C) showed an increased neuronal density in the KO mice (B) when compared to the WT mice (A) with treatment, which agrees with the KO mouse phenotype. IHC stains for GFAP (D), MSA (E), and Mac-3 (F) all showed reduced neuroinflammation with RS 102895 treatment. * indicates p < 0.05 using Student’s t test, n is 6 for each point and data is presented ± SEM.