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. 2014 Jul 21;111(31):11383–11388. doi: 10.1073/pnas.1321433111

Fig. 2.

Fig. 2.

Sema1a enhances Fas2-mediated cell–cell adhesion. (A) Cells transfected with YFP expression construct did not form large cell aggregates (i.e., an aggregate with the size of >20 cells). (B) Cells expressing Fas2-YFP formed large cell aggregates (>20 cells). (C) Coexpression of Sema1a greatly increased the frequency of Fas2-induced cell aggregates and the size of aggregates. (D) Coexpression of a Sema1a mutant lacking a large portion of the cytoplasmic domain did not enhance Fas2-induced cell–cell aggregation. (E) The percentage of Fas2-positive cells that formed large cell aggregates (>20 cells) were quantified. The bar for YFP-transfected cells did not show up as no large cell aggregate (>20 cells) was observed. *P = 0.0019. (Scale bar, 20 μm.) Error bars: SEM.