Skip to main content
. 2014 Jul 21;111(31):11527–11532. doi: 10.1073/pnas.1322016111

Fig. 3.

Fig. 3.

Functional interaction between brain histamine and OEA. (A) Effect of OEA administration on histamine release in the prefrontal cortex of freely moving mice. Represented are means ± SEM of three fasted and four fed ad libitum mice. (B) Effect of ABT-239 and OEA–ABT-239 on cortical histamine release in freely moving mice. Represented are means ± SEM of four and five mice, respectively. ABT-239 and OEA were administered i.p. separately and α-FMH (5 µg) was administered i.c.v. Baseline histamine release was not detectable in α-FMH–treated mice or during ABT-239 administration (dashed line; n = 4). Experiments were carried out between 0900 and 1600 h. ***P < 0.001, **P < 0.01, *P < 0.05, vs. baseline values; ##P < 0.01 vs. ABT-239, two-way ANOVA and Bonferroni’s test. For clarity, we reported only the significant differences vs. the last baseline sample before drug treatment, although differences were significant vs. all baseline samples.