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. Author manuscript; available in PMC: 2014 Aug 11.
Published in final edited form as: Cardiovasc Toxicol. 2012 Jun;12(2):108–114. doi: 10.1007/s12012-011-9144-9

Fig 6. NQO1 Inhibitor Dicoumarol Potentiats Dox Induced Caspase.

Fig 6

Primary cultured cardiomyocytes were treated with dicoumarol (Dic) from 0.01 to 10 µM with or without 0.8 µM Dox for 16 hrs (A). Cells were pretreated with 10 µM PG in the presence or absence of 1 µM dicoumarol before 16 hrs treatment with 0.8 µM Dox (B). Cells were harvested for measurements of caspase activity using DEVD-AMC as a substrate as described in the Method. The means labeled with different letters indicate statistic significance as described in Fig 3.