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. Author manuscript; available in PMC: 2014 Aug 11.
Published in final edited form as: Eur J Med Chem. 2014 Apr 4;79:184–193. doi: 10.1016/j.ejmech.2014.04.009

Fig. 2.

Fig. 2

X-ray crystal structure of hIDE-CF co-crystallized with 1 (PDB code: 4DTT). A) general view, B) detailed interactions at the exosite C) detailed interactions at the catalytic site. Zn (red sphere); O (red); N (blue); C (cyan for IDE N-terminal domain, gray for IDE C-terminal domain, orange for 1); hydrogen contacts in dotted lines. Arrows point residues shown to be critical by mutagenesis.