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Modification of hIDE peptidolytic profile by 5 (BDM43079) measured on full unlabelled native substrates.
A) amyloid-β1–40, B) insulin C) IGF-II, D) somatostatin, E) glucagon. Values are given as the mean of 3 experiments. [hIDE] = 7.5 µg/mL. [5] = 100 µM; [EDTA] = 50 mM. EDTA inhibits hIDE independently of the substrate’s nature by chelating the zinc, whereas 5 behaves either as an activator or an inhibitor depending of the substrate.
