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. Author manuscript; available in PMC: 2014 Aug 11.
Published in final edited form as: Eur J Med Chem. 2014 Apr 4;79:184–193. doi: 10.1016/j.ejmech.2014.04.009

Scheme 1.

Scheme 1

a Synthesis of carboxylic acids 1–7.

a Reactants and conditions : a) R-Br, MeOH, DIEA or TEA or KOH, room temp., 2–12 h b) trifluoroacetic anhydride 2% in acetic anhydride, 20–70 °C, 5h, 100%. c) histidine derivative or phenylalanine methyl ester, anhydrous DIEA, anhydrous DMF, Argon, room temp., overnight. d) TFA 5%/DCM, triisopropylsilane, 1 h, room temp. e) MeNH2/EtOH, MeOH, reflux. f) i. 80/20 MeOH/SOCl2, overnight, room temp. ii. Benzoylchloride, DIEA, CH2Cl2 overnight, room temp. iii. NaOH, MeOH, H2O.