Table 1.

Inhibition of the hydrolysis of Aβ16–23 by IDE by 1–7.

Cmpd	R1−	Ar	-R2	IC50 Aβ16–23 hydrolysis [µM] [a]
1 (BDM41367)			-OCH3	2.9 ± 1.9
2			-OCH3	1.4 ± 1.3
3			-OCH3	0.6 ± 0.9
4			-NHCH3	0.6 ± 0.6
5 (BDM43079)			-NHCH3	0.1 ± 0.5
6			-OCH3	> 100
7			-OCH3	> 100

^[a]IC₅₀ values are given as the mean standard error from 3–7 independent experiments performed in quadruplicate.