FIG. 2.

Clinical presentation of glioblastoma multiforme (GBM) tumors. Histology images of brain tissue stained using hematoxylin and eosin: (A) GBM cells seen around blood vessels (labeled brown (collagen IV) via immunoperoxidase staining and indicated by black arrows). (B) GBM cells seen below the surface of pia mater (sub-pial spread). (C) GBM cells migrating along white matter tracts (labeled blue via Luxol fast blue). (D) Histology image of a normal brain cortical tissue showing sparsely populated neurons, preserved cellularity and architectures as opposed to (A–C) that show extensive tumor cell infiltration, disruption of normal architectures, and hypercellularity. Color images available online at www.liebertpub.com/teb