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. 2014 May 28;1:231–242. doi: 10.1016/j.toxrep.2014.05.010

Fig. 6.

Fig. 6

Co-exposure to Cd and B[a]P resulted in significant increases in gene expression at 1 μM Cd × 1 μM B[a]P in (A) CYP1A1 (B) CYP1B1, (C) EPHX1, and (E) MT2A. There were no significant changes in gene expression at any concentration in (D) MT1A. Cells were exposed to 1 μM Cd alone for 24 h followed by a 24 h exposure to defined concentrations of B[a]P. Bars represent mean fold expression (n = 3) ± SEM. All genes of interest were normalized to ACTB. The expression of genes in the DMSO control group was set to 1. * Indicates significant difference from 1 μM Cd × 1 μM B[a]P, p < 0.001, † indicates significant difference from 1 μM Cd × 1 μM B[a]P, p < 0.01, and # indicates significant difference from 1 μM Cd × 1 μM B[a]P, p < 0.05.