Figure 4. ADAM10 deficiency enhances SCF-induced proliferation and survival.
(A) WT and ADAM10 KO BMMC were treated with 1ng/ml IL-3 and varying amounts of SCF as indicated for 4 days. Live cell numbers were measured by cell counting. (B) Survival of WT and ADAM10 KO BMMC was measured using various amounts of SCF as indicated over the course of 3 days. Data shown in A and B means and SEM of 15–18 samples from 2 independent experiments. *p <.05; **p<.01; ***p <.001.