Table 1.

National Institutes of Health/National Heart, Lung, and Blood Institute–Sponsored ISCHEMIA Trial Criteria for Moderate-Severe Ischemia

Nuclear Perfusion	Echocardiographic Wall Motion	Cardiac Magnetic Resonance Perfusion or Wall Motion
≥10% ischemic myocardium	≥3 of 16 segments with stress-induced hypokinesis or akinesis*	≥4 of 32 stress perfusion defects (≥2 of 16 segments) or ≥3 dobutamine-induced dysfunctional segments (out of 16 segments)

^*The one exception to the characterization of ischemic wall motion change is that when segments change from akinetic to dyskinetic during stress in the absence of demonstration of a biphasic response, this is considered a nonspecific response rather than an ischemic response.