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. Author manuscript; available in PMC: 2015 Apr 4.
Published in final edited form as: J Proteomics. 2014 Jan 9;100:55–59. doi: 10.1016/j.jprot.2013.12.022

Figure 2.

Figure 2

The use of DNA shearing in AP sample preparation enhances the identification by mass spectrometry of chromatin-bound interactors for core histone proteins. A heat map of the interaction partners identified with each histone bait using the “standard” or chromatin optimized AP approach (Avg SAINT ≥ 0.8) was generated using MeV 4.81. The pixel color corresponds to the total number of peptides (spectral counts) detected for a given prey across all replicates. Interactor localization and functions, as defined by GO annotation, is highlighted below the heat map.