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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Bioorg Med Chem. 2014 May 23;22(15):4257–4268. doi: 10.1016/j.bmc.2014.05.036

Scheme 1.

Scheme 1

Synthesis of N6 substituted apioadenosines. Reagents and conditions: (a) (i) appropriate benzyl bromide, DMF, 50 °C, 48 h; (ii) 25% NH4OH, 50 °C, 48 h or 90 °C, 3 h, 20–56% over two steps; (b) (i) appropriate benzyl bromide, DMF, rt, 48 h; (ii) 25% NH4OH, 50 °C, 24 h, 8–21% over two steps.