Table 2.

Statistically significant trends in mutation patterns^§ involving novel SMGs identified in non-ultramutated ECs in the TCGA study [7]

Molecular Subgroup	Gene Pair	Trend in Mutation Pattern §	p-value§
Hypermutated/MSI	ARID5B-ZFHX3	Co-occurrence	0.035
	CTCF-FGFR2	Co-occurrence	0.025
	FBXW7-LIMCH1	Co-occurrence	0.021
	BCOR- PPP2R1A	Co-occurrence	0.006
	HIST1H2BD -RPL22	Co-occurrence	0.005
	SPOP-RPL22	Co-occurrence	0.016
	SPOP-CCND1	Co-occurrence	0.005
	SPOP-PPP2R1A	Co-occurrence	0.040
	MECOM-PPP2R1A	Co-occurrence	0.021
	MECOM-ATR	Co-occurrence	0.0004
	METTL14-FGFR2	Co-occurrence	0.048
	METTL14-PPP2R1A	Co-occurrence	0.021
	SGK1-RBMX	Co-occurrence	0.013
	TNFAIP6-MECOM	Co-occurrence	0.046
	TNFAIP6-METTL14	Co-occurrence	0.046
Copy number low/MSS	SPOP-PTEN	Mutual exclusivity	0.029
	SOX17-CTNNB1	Mutual exclusivity	0.043
	FBXW7-CTNNB1	Mutual exclusivity	0.022
	FBXW7-SOX17	Co-occurrence	0.047
	MECOM-PIK3R1	Co-occurrence	0.011
Copy number high/serous-like	CHD4-FBXW7	Co-occurrence	0.009
	GIGYF2-TP53	Mutual exclusivity	0.001
Ultramutated	ZFHX3-PIK3CA	Co-occurrence	0.015
	ZFHX3-ATR	Co-occurrence	0.029
	GIGYF2-CSDE1	Co-occurrence	0.004
	SGK1-CTNNB1	Co-occurrence	0.017
	ATR-CTNNB1	Co-occurrence	0.017
	CSDE1-FGFR2	Co-occurrence	0.041
	GIGYF2-FGFR2	Co-occurrence	0.041
	LIMCH1-PPP2R1A	Co-occurrence	0.020
	SPOP-KRAS	Mutual exclusivity	0.009
	RBMX-KRAS	Mutual exclusivity	0.029
	CCND1-RPL22	Co-occurrence	0.014

^§Data were obtained from the cBioCancer Genomics Portal [32,33]; SMGs identified in the ultramutated subgroup were not included in the input query. Only gene-pairs demonstrating a p-value <0.05, as derived via Fisher's Exact test are shown; p-values are not adjusted for FDR.