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. 2014 Jul 26;11:133. doi: 10.1186/1742-2094-11-133

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Copyright © 2014 Rojas et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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CD86 and Ym1 expression in the retina after 15 days of unilateral laser-induced OHT. Double immunostaining: Iba-1/CD86 (A-I) and MHC-II/Ym1 (J-L). Retinal whole-mount. In contralateral eyes (A-C) CD86 immunostaining was observed in some ameboid Iba-1+ cells in the OS (blank arrowhead) and NFL-GCL (inset). In OHT eyes (D-I) rounded Iba-1+ cells (arrow) and most ameboid Iba-1+ cells (blank arrowhead) were CD86+. Ym1 immunoreaction (J-L) was restricted to a few ameboid Iba-1+ cells (blank arrowhead) in the NFL-GCL of OHT eyes. (NFL-GCL: nerve fiber layer-ganglion cell layer; OHT: ocular hypertension; OS: photoreceptor outer segment).