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. 2014 Jul 26;11:133. doi: 10.1186/1742-2094-11-133

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Copyright © 2014 Rojas et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Iba-1+ cells in the IPL after 15 days of unilateral laser-induced OHT. Iba-1 immunostaining. Retinal whole-mounts. Most Iba-1+ cells in the IPL were ramified and there were few Iba-1+ cells with a dendritic-like appearance (arrow in C, F, I). In comparison with naïve eyes (A-C), ramified Iba-1+ cells in the IPL of contralateral eyes and OHT eyes formed a denser cellular mosaic (D, E, G, H). Both ramified and dendritic-like Iba-1+ cells exhibited morphological signs of cell activation (process retraction and increased secondary and superior order processes) that were more pronounced in OHT eyes (G-I) than in contralateral eyes (D-F). (IPL: inner plexiform layer; OHT: ocular hypertension).