Table 5.
Functional annotation clustering of down-regulated genes
|
Annotation cluster 1 |
Enrichment score: 1.38 |
|
|
|
|---|---|---|---|---|
| Category | Term | Count | % | P value |
| SP_PIR_KEYWORDS |
Disulfide bond |
8 |
38 |
0.014 |
| SP_PIR_KEYWORDS |
Glycoprotein |
9 |
43 |
0.034 |
| UP_SEQ_FEATURE |
Signal peptide |
8 |
38 |
0.035 |
| SP_PIR_KEYWORDS |
Signal |
8 |
38 |
0.037 |
| UP_SEQ_FEATURE |
Glycosylationsite: N-linked (GlcNAc…) |
8 |
38 |
0.072 |
| UP_SEQ_FEATURE | Disulfide bond | 6 | 29 | 0.117 |
The functional annotation of mRNA expression profile was conducted by DAVID software (http://david.abcc.ncifcrf.gov) [30,31]. Annotation Cluster: A group of terms having similar biological functions. Enrichment Score: The geometric mean (in -log scale) of member's p-values in a corresponding annotation cluster represents the rank of their biological significance. An enrichment score of >1.3 is used for a cluster to be statistically significant. The higher an enrichment score, the more enriched genes in that group. P-Value: The p-values associated with each annotation terms are the Fisher Exact Score shown in the regular chart report for the same terms. Count: Genes involved in the terms. %: Percentage of involved genes over total down-regulated genes correlated to altered miRNAs.