Table 2.

Summary of p16 alterations in chemically-induced HCP tumors.

Sample	p160 Status	Methylation Exon 1α	Point Mutations Exons 1α and Exon 2
184 2L T1	+/+	Yes	No
184 2R T1	+/+	No	No
184 2R T2	+/+	No	No
184 3L T1	−/−	No	No
184 3L T2	−/−	No	No
184 3R T1	+/+	No	No
185 1R T1	−/−	No	No
185 1R T2	+/+	No	No
185 2R T1	+/+	Yes	No
185 2R T2	−/−	No	No
185 3L T1	−/−	No	No
186 1R T1	+/+	No	No
186 1R T3	+/−	Yes	No
186 2L T1	+/+	No	No
186 3R T1	−/−	No	No
186 3R T2	+/+	Yes	No
187 1R T1	−/−	No	No
187 3R T1	+/−	No	No
188 1L T1	+/−	No	No
188 1L T2	+/+	Yes	No
188 1R T1	+/+	Yes	No
188 2L T1	−/−	No	No
188 2L T2	+/+	No	D74FS*
188 2R T3	+/+	No	No
188 3L T1	+/+	Yes	No
188 3L T2	−/−	No	No
188 3L T4	+/+	No	No
189 1L T1	−/−	No	No
189 2L T1	+/+	Yes	No
190 1R T1	+/+	No	No
190 3L T1	+/+	No	No
190 3L T2	+/+	Yes	No
190 3R T1	+/−	No	No
190 3R T2	−/−	No	No

^*FS, frame shift.