Chromatographic analysis of donated and synthesized 4,4'-DMAR. A–C: GC-MS analysis confirmed that the donated 4,4'-DMAR HCl was consistent with the synthesized (±)-cis-4,4'-DMAR standard. Conversion of the hydrochloride salt to the free base (trace B) improved detectability. D and E: LC-ESI-quadrupole-MS/MS analysis in MRM mode to obtain separation. F and G: LC-single quadrupole-MS analysis of the donated (±)-cis-4,4'-DMAR HCl and improved separation of cis and trans racemates.
247×302mm (300 × 300 DPI)