. Author manuscript; available in PMC: 2015 Jul 1.

Published in final edited form as: Drug Test Anal. 2014 May 19;6(0):684–695. doi: 10.1002/dta.1668

Table 1.

Stimulation of release in rat brain synaptosomes

Drug	Release at DAT EC₅₀ (nM)^a	Release at NET EC₅₀ (nM)^a	Release at SERT EC₅₀ (nM)^a	DAT/SERT ratio^b
d-Amphetamine	5.5 ± 0.5	8.2 ± 1.6	2602 ± 494	473
Aminorex	9.1 ± 0.9	15.1 ± 3.5	414 ± 78	45
(±)-cis-4-MAR	1.7 ± 0.2	4.8 ± 0.9	53.2 ± 6.8	31
(±)-cis-4,4'-DMAR	8.6 ± 1.1	26.9 ± 5.9	18.5 ± 2.8	2

Data are expressed as mean ± SD for N = 3–4 experiments performed in triplicate.

DAT/SERT ratio calculated by (EC₅₀ at DAT)⁻¹/(EC₅₀ at SERT)⁻¹; higher value indicates greater DAT selectivity.