Figure 1. Initial clustering of GPCR proteins and phylogenetic tree of all α₂-adrenoceptors.

Panel A presents two-dimensional projection of the CLANS clustering results obtained for the GPCR proteins, a clan corresponding to α₂-adrenoceptors is indicated by an ellipse. Panel B presents two-dimensional projection of the CLANS clustering of α₂-adrenoceptors. Panel C presents the postulated phylogenetic tree of the α₂-adrenoceptor family. Only the major branches corresponding to subfamilies are shown. Values at the nodes indicate the statistical support for the particular branches, according to the bootstrap test. The human rhodopsin sequence was used for rooting the tree.