Figure 3. Predicted models of filamin-2 (FLN2) and α2C-adrenoceptor (ADRA2C) proteins, and their complex.
Panels A and B present cartoon diagram of FLN2 (region between residues 1982 and 2183) and ADRA2C protein models. Positively and negatively charged regions are indicated by blue and red colors, respectively. Panel C presents whole protein-protein complex predicted by HADDOCK program. Panel D shows the interaction between receptor's C-terminal helix and the filamin-2 region that is responsible for binding the receptor.