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. 2014 Aug 11;9(8):e101955. doi: 10.1371/journal.pone.0101955

Figure 2. MCF10A and MCF10AT acini have different architectural and mechanical properties.

Figure 2

Confocal immunofluorescence images of (A) non-malignant MCF10A (hollow lumen) and (B) pre-malignant MCF10AT (filled lumen) acini, taken after 15 days of growth. Scale bars 25 µm. (C) Creep compliance (mean ±95% CI) of hollow and filled breast epithelial acini. (N = 32 and 31 acini for A and T respectively) (D) Differences in mechanical response could be due to (1) different properties of single cells (2) changes in connectivity or (3) changes in multicellular architecture.