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Reduction of ‘off’-time in advanced PD patients. (A) Adjusted mean change in the percentage of ‘off’-time over time in patients with advanced Parkinson disease (PD), full analysis set (FAS) (last observation carried forward, LOCF); (B) Adjusted mean duration (±SE) of ‘off’-time. For A and B: No difference was observed in the adjusted mean percentage ‘off’-time or duration between the two arms at any study visit (ANCOVA).
