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KRAS fluorescence in situ hybridization. (a) KRAS amplification; numerous KRAS (orange) signals and two CEP12 (green) signals per nucleus. (b) Example of a case with KRAS amplification and chromosome 12 hyperploidy; numerous orange and green signals in each nucleus. (c) Example of a case with KRAS amplification and chromosome 12 monosomy; numerous KRAS (orange) signals and only one CEP12 (green) signal per nucleus.
