Table 2.
KRAS FISH results in conventional ductal and undifferentiated pancreatic carcinomas
| KRAS FISH (n = 45) | Ductal adenocarcinomas (n = 21) | Undifferentiated carcinomas (n = 24) | P-value |
|---|---|---|---|
| Amplification | 0 | 10a | 0.0007 |
| Hyperploidy | 2 | 5 | |
| Monosomy | 4 | 1 | |
| Normal | 15 | 8 | 0.0017 |
Abbreviations: FISH, fluorescence in situ hybridization.
a
In three cases, amplification was associated with chromosome 12 monosomy (46.7–62.3% of cells) and in another three cases, amplification was associated with chromosome 12 hyperploidy (47.7–64.5% of cells).