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. 2014 Aug 11;9(8):e102087. doi: 10.1371/journal.pone.0102087

Table 1. Specific amino acid residues for atypical substrates at ar/R constrictions and P1–P5 positions (based on [4]).

Aquaporins	Putative substrates	ar/R constrictions (filter 2)				P1–P5 positions
		TMH2	TMH5	LE1	LE2	P1	P2	P3	P4	P5
VvTnPIP1;4	Boron, CO₂, H₂O₂, urea	F⁹⁴	H²²³	T²³²	R²³⁸	Q¹⁵⁴	S²³⁹	A²⁴³	F²⁵⁸	W²⁵⁹
VvTnPIP2;1	Boron, CO₂, H₂O₂, urea	F⁸⁴	H²¹³	T²²²	R²²⁸	Q¹⁴⁴	S²²⁹	A²³³	F²⁴⁸	W²⁴⁹
VvTnPIP2;3	Boron, CO₂, H₂O₂, urea	F⁸⁷	H²¹⁶	T²²⁵	R²³¹	Q¹⁴⁷	S²³²	A²³⁶	F²⁵¹	W²⁵²
VvTnTIP1;1	Urea, NH₃, H₂O₂	H⁶⁵	I¹⁸⁷	A¹⁹⁶	V²⁰²	T¹²⁵	S²⁰³	A²⁰⁷	V²¹⁹	W²²⁰
VvTnTIP2;2	Urea, NH₃, H₂O₂	H⁶³	I¹⁸⁵	G¹⁹⁴	R²⁰⁰	T¹²³	S²⁰¹	A²⁰⁵	V²¹⁷	W²¹⁸
VvTnTIP4;1	Urea, NH₃, H₂O₂	H⁶⁰	V¹⁸³	A¹⁹²	R¹⁹⁸	T¹²⁰	S¹⁹⁹	A²⁰³	V²¹⁵	W²¹⁶