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. 2014 Aug 11;9(8):e104313. doi: 10.1371/journal.pone.0104313

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© 2014 Chirakul et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) The virulence of the B. pseudomallei K96243 wild-type and bprD mutant strains was compared in BALB/c mice, which are highly susceptible to infection. X-axis, days after infection; Y-axis, % survival. BALB/c mice (groups of eight) were intraperitoneally infected with ∼10⁴ CFU of the B. pseudomallei K96243 wild-type (•), bprD mutant (∇) or bprD complemented (▪) strain, and their survival was monitored daily. The survival of mice infected with the wild-type strain was significantly different from those infected with the bprD mutant (P = 0.0015). (B) The numbers of B. pseudomallei K96243 wild-type, bprD-mutant, and bprD-complemented strains in the spleen of BALB/c mice. X-axis, days after infection; Y-axis, number of bacteria (CFU). A total of 1×10⁴ CFU of the wild-type (▪) and bprD-mutant (□) strains, and 0.5×10⁴ CFU of the bprD-complemented ( ) strain, were intraperitoneally injected into BALB/c mice. The number of bacteria in the spleen on days 2, 3, 7 and 13 was determined. The experiment was performed twice; average values of data are shown.

Inline graphic — (A) The virulence of the B. pseudomallei K96243 wild-type and bprD mutant strains was compared in BALB/c mice, which are highly susceptible to infection. X-axis, days after infection; Y-axis, % survival. BALB/c mice (groups of eight) were intraperitoneally infected with ∼10⁴ CFU of the B. pseudomallei K96243 wild-type (•), bprD mutant (∇) or bprD complemented (▪) strain, and their survival was monitored daily. The survival of mice infected with the wild-type strain was significantly different from those infected with the bprD mutant (P = 0.0015). (B) The numbers of B. pseudomallei K96243 wild-type, bprD-mutant, and bprD-complemented strains in the spleen of BALB/c mice. X-axis, days after infection; Y-axis, number of bacteria (CFU). A total of 1×10⁴ CFU of the wild-type (▪) and bprD-mutant (□) strains, and 0.5×10⁴ CFU of the bprD-complemented ( ) strain, were intraperitoneally injected into BALB/c mice. The number of bacteria in the spleen on days 2, 3, 7 and 13 was determined. The experiment was performed twice; average values of data are shown.