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. 2014 Aug 11;9(8):e104433. doi: 10.1371/journal.pone.0104433

Figure 3. The effects of maternal immune activation on social behavior in the three-chamber social interaction test.

Figure 3

(A) diagrammatic depiction of the experimental set-up for the social interaction test. (B) Male and female saline-treated mice showed the expected preference for the social zone (**p<0.01; ***p<0.001; ****p<0.0001). However, compared to saline-treated controls, female LPS and Poly IC offspring showed no significant preference for the social zone over the non-social zone. A loss of the normal social interaction behavior was also observed in male Poly IC mice, but not in male LPS mice compared to control mice. Each column represents mean ± S.E.M.