Table 1. Detailed characteristics of studies included in this meta-analysis.
| Genotypes distribution (Cases/controls) | |||||||||||||||
| Study [Reference] | Year | Country | Ethnicity | Study | HWE | Total sample | ε2/ε2 | ε2/ε3 | ε3/ε3 | ε2/ε4 | ε3/ε4 | ε4/ε4 | ε2 | ε3 | ε4 |
| type | Case/Control | ||||||||||||||
| Utermann1984[20] | 1984 | Germany | Caucasion | HCC | Yes | 523/1031 | 7/120 | x68/124 | 333/617 | 11/15 | 92/236 | 12/29 | 86/359 | 493/977 | 115/280 |
| Cumming1984[21] | 1984 | Scotland | Caucasion | PCC | Yes | 239/400 | 0/2 | 18/51 | 128/233 | 10/11 | 77/99 | 6/4 | 28/64 | 223/383 | 93/114 |
| Lenzen1986[22] | 1986 | France | Caucasion | PCC | Yes | 570/624 | 1/6 | 50/67 | 360/393 | 10/20 | 137/125 | 12/13 | 61/93 | 547/585 | 159/158 |
| Eichner 1993[23] | 1993 | USA | Caucasion | PCC | Yes | 114/412 | 0/2 | 16/35 | 67/276 | 0/4 | 30/85 | 1/10 | 16/41 | 113/396 | 31/99 |
| Luc 1994[24] | 1994 | France | Caucasion | PCC | Yes | 574/680 | 3/6 | 54/92 | 352/428 | 14/14 | 133/126 | 18/14 | 71/112 | 539/646 | 165/154 |
| Hergenc 1995'[25] | 1995 | Turkey | Caucasion | HCC | Yes | 50/60 | 0/0 | 7/6 | 41/47 | 0/2 | 2/5 | 0/0 | 7/8 | 50/58 | 2/7 |
| Kim 1995[26] | 1995 | Korea | Asian | HCC | Yes | 97/137 | 2/1 | 17/25 | 57/95 | 0/4 | 20/12 | 1/0 | 19/30 | 94/132 | 21/16 |
| Nakai 1998[27] | 1998 | Japan | Asian | PCC | Yes | 254/422 | 0/0 | 10/16 | 178/327 | 2/4 | 52/74 | 6/1 | 12/20 | 240/417 | 60/79 |
| Scaglione1999[28] | 1999 | Italy | Caucasion | HCC | No | 98/98 | NR | NR | NR | NR | NR | NR | 3/3 | 84/87 | 11/8 |
| Lambert 2000[29] | 2000 | France | Caucasion | PCC | Yes | 567/678 | 3/4 | 67/100 | 332/420 | 0/3 | 152/138 | 18/13 | 70/107 | 551/658 | 170/154 |
| Benes2000[30] | 2000 | Czech | Caucasion | PCC | Yes | 114/222 | 1/0 | 12/30 | 71/147 | 3/2 | 23/43 | 4/0 | 16/32 | 106/220 | 30/45 |
| Batalla 2000[31] | 2000 | Spain | Caucasion | PCC | Yes | 220/200 | 0/0 | 9/18 | 174/151 | 1/1 | 32/28 | 4/2 | 10/19 | 215/197 | 37/31 |
| Raslová 2001[32] | 2001 | Canada | Caucasion | PCC | Yes | 69/69 | 2/1 | 8/5 | 46/47 | 1/0 | 11/15 | 1/1 | 11/6 | 65/67 | 13/16 |
| Bai 2001[33] | 2001 | China | Asian | PCC | Yes | 47/50 | 0/0 | 4/5 | 40/39 | 0/0 | 6/3 | 0/0 | 4/5 | 50/47 | 6/3 |
| Freitas 2002[34] | 2002 | Australia | Caucasion | PCC | Yes | 411/624 | 3/4 | 24/67 | 254/372 | 9/15 | 111/147 | 10/19 | 36/86 | 389/586 | 130/181 |
| Mamotte 2002[35] | 2002 | Australia | Caucasion | PCC | Yes | 359/639 | 4/4 | 24/68 | 217/383 | 7/16 | 96/149 | 11/19 | 35/88 | 337/600 | 114/184 |
| Kolovou 2002[36] | 2002 | Greece | Caucasion | PCC | Yes | 124/240 | 0/0 | 3/34 | 94/159 | 0/5 | 27/40 | 0/2 | 3/39 | 124/233 | 27/47 |
| Keavney 2003[37] | 2003 | UK | Caucasion | PCC | Yes | 4487/5757 | NR | 440/686 | 2566/3384 | NR | 1206/1376 | NR | 440/686 | 4212/5446 | 1206/1376 |
| Kolovou 2003[38] | 2003 | Greece | Caucasion | PCC | Yes | 165/165 | 0/0 | 3/16 | 129/118 | 1/4 | 29/23 | 1/0 | 4/20 | 161/157 | 31/27 |
| Kumar 2003[39] | 2003 | India | Caucasion | PCC | Yes | 35/45 | 0/2 | 6/9 | 12/32 | 1/0 | 6/0 | 10/2 | 7/9 | 24/41 | 17/2 |
| Marques 2003[40] | 2003 | France | Caucasion | HCC | Yes | 400/338 | NR | NR | 272/228 | NR | NR | NR | 37/40 | 272/228 | 91/70 |
| Keavney 2004[41] | 2004 | UK | Caucasion | PCC | Yes | 4685/3460 | NR | 440/406 | 2566/1949 | 1206/810 | NR | NR | 1646/1216 | 3006/2355 | 1206/810 |
| Ranjith 2004[42] | 2004 | South Africa | Caucasion | PCC | Yes | 195/300 | 0/3 | 7/18 | 139/228 | 3/3 | 45/43 | 1/5 | 10/24 | 191/289 | 49/51 |
| Baum 2006[43] | 2006 | China | Asian | PCC | Yes | 231/331 | 0/2 | 13/60 | 164/203 | 4/6 | 46/39 | 4/1 | 17/68 | 223/302 | 54/46 |
| Aasvee 2006[44] | 2006 | Estonia | Caucasion | PCC | Yes | 71/85 | 1/1 | 4/13 | 45/52 | 2/3 | 16/16 | 3/0 | 7/17 | 65/81 | 21/19 |
| Koch 2008[45] | 2008 | Germany | Caucasion | PCC | Yes | 3657/1211 | 26/7 | 402/164 | 2279/736 | 63/23 | 809/263 | 78/18 | 491/194 | 3490/1163 | 950/304 |
| Kolovou 2009[46] | 2009 | Greece | Caucasion | PCC | Yes | 124/240 | NR | NR | NR | NR | NR | NR | 5/19 | 106/197 | 13/24 |
| Bahri 2008[47] | 2008 | Tunisia | Caucasion | PCC | Yes | 80/100 | 0/0 | 6/8 | 61/78 | 0/1 | 13/13 | 0/0 | 6/9 | 80/199 | 13/14 |
| Martinelli 2009[48] | 2009 | Italy | Caucasion | HCC | Yes | 394/287 | NR | NR | NR | NR | NR | NR | 34/25 | 285/220 | 76/42 |
| Al-Bustan 2009[49] | 2009 | Kuwaiti | Caucasion | HCC | No | 88/122 | 4/9 | 2/2 | 72/98 | 2/3 | 8/9 | 0/1 | 6/11 | 90/33 | 16/5 |
| Onrat 2012[50] | 2012 | Turkey | Caucasion | PCC | Yes | 36/100 | 0/0 | 12/4 | 72/27 | 0/0 | 16/4 | 0/1 | 12/4 | 100/35 | 16/5 |
| Tanguturi 2013[51] | 2013 | USA | Caucasion | HCC | Yes | 202/210 | 0/0 | 8/14 | 142/167 | 4/3 | 37/23 | 11/3 | 12/17 | 187/204 | 52/29 |
| Zende 2013[52] | 2013 | India | Caucasion | HCC | No | 150/150 | 6/7 | 13/16 | 59/85 | 7/4 | 22/14 | 43/24 | 26/27 | 94/115 | 72/42 |
HWE, Hardy-Weinberg equilibrium; NR, not reported; Cases, MI patients; HCC, hospital based case-control study; PCC, population based case-control study.