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Illustration of DOC2B and Munc13-1 impact on network-bursting activity shows divergent effects. While DOC2B enhances the activity within network bursts, it does not change the occurrence of network bursts (A; DOC2B-black, control-gray). However, Munc13-1 decreases the network spiking activity within the burst but enhances bursts frequency (B; Munc13-1: dark gray, control: light-gray). The network-burst profiles are based on the average firing rates in Figures 3 and 7.
